January 28, 2012

Repetition is the curse of the doctor-patient engagement

Repetition is the curse of the doctor patient engagement

How many times as a doctor do you ask the same questions over and over again as part of the routine process of taking a history from your patient?  And how often as a patient do you have to answer those same questions each time you see a new doctor? How long does this take, given that doctors and patients both complain that there is too little time for the modern consultation to cover all the bases to the satisfaction of both parties?


Read the rest of Repetition is the curse of the doctor-patient engagement on KevinMD.com.


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Erin Brockovich Tackles Mass Hysteria Case

That Erin Brockovich is getting a lot of media attention for investigating the mysterious symptoms that are affecting 15 teens in a small town in western New York shouldn't be surprising. It is an interesting case.

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Patients will understand an honest mistake if the doctor tells the truth

Patients will understand an honest mistake if the doctor tells the truth

It was 1976 and I was a junior resident in urology at Baylor College of Medicine in Houston, Texas.  I was assigned to a rotation in pathology where my job was to process specimens taken at surgery, dictate a gross description of the specimen and then place the specimens into the cassettes that would be used to make the permanent sections.  I was transferring a prostate biopsy, approximately 0.5mm x 10mm, and it slipped from the forceps and was washed down the drain of the sink.  I searched for the tiny sliver of tissue and even took the drain trap apart but could not locate it.  I felt terrible and told the director of the pathology lab who recommended that I call the urologic surgeon, Dr. Seybold, and report what had happened with the biopsy.


Read the rest of Patients will understand an honest mistake if the doctor tells the truth on KevinMD.com.


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Safety Saturday

Thin Ice - Photo by Images Etc Ltd/Getty ImagesParents can certainly learn a lesson from some of these accidents and tragedies, such as that a mild winter equals thin ice on most ponds, which means you shouldn't go for a stroll on the ice with your family. Also, gun powder and kids aren't a good mix.

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January 27, 2012

Cold and Flu Season Update

Flu Map - Photo courtesy of the CDCThe CDC reports that flu activity continues at a "relatively low" level through most of the country.

They do also report that "increases in activity are expected in the coming weeks," and it is easy to see signs of that increased flu activity already, with:

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The Canadian Paediatric Society Concussion Recommendations

"If in doubt, sit them out."

That slogan sums up the advice from the Canadian Paediatric Society on the management of concussions, which includes that young children and teens with a concussion should:

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Youth Football Head Impact Concussion Study

Stone Phillips with Members of the Auburn Eagles of Montgomery County, VA - Photo courtesy of StonePhillipsReports.com Concussions are becoming a more recognizable problem lately.

In addition to recognizing when kids actually have concussions, parents, coaches, and players are more aware of the long-term consequences of having a concussion, especially of having multiple concussions.

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Dosage for Infants' Tylenol

New Acetaminophen Concentrations - Photo courtesy of the FDAIf you are lucky enough to find any, you may find that there are three different concentrations of infants' acetaminophen on store shelves right now.

A new Infants' Tylenol Oral Suspension (160mg/5ml) replaces the older, more concentrated Infants' Concentrated Tylenol Drops, which was available at 80mg per 0.8ml. In addition, another concentration of infants' acetaminophen drops has been available, at 80mg per 1.0ml.

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How to evaluate a patient with chronic cough?

Initial evaluation of chronic cough (defined as more than 8 weeks' duration in adults and 4 weeks in children) should include a chest radiography (CXR) in most adult patients.

Patients who are taking an angiotensin-converting enzyme inhibitor (ACEi) should switch to a medication from another drug class.



Differential diagnosis of cough, a simple mnemonic is GREAT BAD CAT TOM. Click here to enlarge the image: (GERD (reflux), Laryngopharyngeal Reflux (LPR), Rhinitis (both allergic and non-allergic) with post-nasal drip (upper airway cough syndrome), Embolism, e.g. PE in adults, Asthma, TB (tuberculosis), Bronchitis, pneumonia, pertussis, Aspiration, e.g foreign body in children, Drugs, e.g. ACE inhibitor, CF in children, Cardiogenic, e.g. mitral stenosis in adults, Achalasia in adults, Thyroid enlargement, e.g. goiter, "Thoughts" (psychogenic), Other causes, Malignancy, e.g. lung cancer in adults).

The most common causes of chronic cough in adults are:

- upper airway cough syndrome (post-nasal drip)
- asthma
- gastroesophageal reflux disease (GERD)
- any combination of the above

If upper airway cough syndrome is suspected, a trial of a decongestant and an antihistamine is warranted.

The diagnosis of asthma can be confirmed with a clinical response to empiric therapy with inhaled bronchodilators or corticosteroids (spirometry is generally preferred though).

Empiric treatment for gastroesophageal reflux disease (GERD) should be initiated in lieu of testing for patients with chronic cough and reflux symptoms.

Patients should avoid exposure to cough-evoking irritants, such as cigarette smoke.

Further testing may be indicated if the cause of chronic cough is not identified and includes:

- high-resolution computed tomography (CT) of the chest
- referral to a pulmonologist or an allergist

In children, a cough lasting longer than 4 weeks is considered chronic.

The most common causes of chronic cough in children are:

- respiratory tract infections ("bronchitis" and pneumonia)
- asthma
- rhinitis with post-nasal drip
- gastroesophageal reflux disease (GERD)
- aspirated foreign body is relatively rare but must not be missed

Evaluation of children with chronic cough should include chest radiography (CXR) and spirometry (if older than 5 years of age). Skin prick test for environmental allergies can also be indicated.

References:

Evaluation of the patient with chronic cough. Benich Iii JJ, Carek PJ. Am Fam Physician. 2011 Oct 15;84(8):887-92.

Diagnosis of chronic cough in children


The puzzling overdose

Several readers nailed this one – valproic acid (Depakote).  Valproic acid does cause hyperammonemia

This syndrome can occur with overdoses, but can also occur on apparently stable dosing.

January 26, 2012

Texas Scottish Rite Hospital for Children Amputee Ski Trip

Texas Scottish Rite Hospital for Children Amputee Ski Trip - Photo courtesy of Texas Scottish Rite HospitalWho wouldn't love a ski trip to Colorado?

Heading to the slopes might be second nature for most teens and thanks to Texas Scottish Rite Hospital for Children and American Airlines, a group of teenage amputee patients are going to enjoy a ski trip to Colorado too. The all-expense-paid trip to Winter Park's National Sports Center for the Disabled "allows the patients the opportunity to have fun while fostering a sense of self-confidence, independence and discovery - attributes that can remain with these young adults throughout their lives."

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"Doctors make mistakes. Can we talk about that?" ED physician Brian Goldman's TED talk

Dr. Goldman asks if you know your surgeon's "batting average" of operations with good outcomes. He mentions the three words you never want to hear: "Do you remember?" It's a good TED talk:



Every doctor makes mistakes (just like everyone does). But, says Dr. Goldman, medicine's culture of denial (and shame) keeps doctors from ever talking about those mistakes, or using them to learn and improve. Telling stories from his own long practice, he calls on doctors to start talking about being wrong.

Here are some simple steps to avoid medical errors from a patient's perspective (source: CNN):

1. Say: "My name is Mary Smith, my date of birth is October 21, 1965, and I'm here for an appendectomy."
2. Say: "Please check my ID bracelet."
3. Say: "Please look in my chart and tell me what procedure I'm having."
4. Say: "I want to mark up my surgical site with the surgeon present."
5. Be impolite (this particular piece of advice is obviously controversial).

References:

CNN video: Steps to avoid medical errors


Kansas Measles Outbreak Expands

The Kansas Department of Health and Environment and Finney County Health Department are now reporting that they have identified at least six cases this month in Garden City, which is more than was seen in all of Kansas in 2011.

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Saving money in health care – ACP’s HVCCC

High Value Cost Conscious Care does not just represent a slogan.  HVCCC represents an attitude.  We at ACP believe that physicians can help decrease health care costs.  We see waste in the system and will do our best to decrease the waste.

Yesterday I tweeted - Appropriate Use of Screening and Diagnostic Tests to Foster High-Value, Cost-Conscious Care bit.ly/yIjyP4 via @addthis – must read!

Please read this article.  This represents a real attempt to provide practical guidelines (with a small g) on ways to avoid unnecessary testing.  This article is just the beginning.

We physicians have a responsibility to the nation to decrease costs when doing so has no negative impact on health care.  We must look carefully at eliminating unnecessary testing, drugs and procedures.

From this article I particularly like these quotes:

Finally, it is important to note that the true cost of a test includes not only the cost of the test itself but also the downstream costs incurred because the test was performed (5). For example, an exercise stress test in an asymptomatic patient may result in a false-positive finding that leads to cardiac catheterization, with its attendant costs and risks, but with no proven benefit. Thus, a seemingly inexpensive test can result in substantial costs because of subsequent testing, treatment, or follow-up. In assessing the costs of a diagnostic test, we must consider these downstream costs and savings.

Because of this article's importance, the Annals of Internal Medicine has made the text and the pdf free online!
 

January 25, 2012

The Neuron

A quick overview sheet presented by the Wellcome Trust Blog:

pdf sheet

Asthma Inhalers

Young child using an inhaler without a spacer - Photo courtesty of Vincent Iannelli, MDMany children have asthma attacks in the winter, with common triggers being cold weather or simply getting a cold or the flu.

That makes this a good time to look at your child's asthma inhalers to make sure he is using the right ones and is using them correctly.

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January 24, 2012

Recall of Infant Rattles

Infant Rattles Recall - Photo courtesy of the CPSCAbout 25,000 infant rattles that were imported by the Lee Carter Co. have been recalled because "the rattle's handle is small enough to fit into a child's throat, posing a choking hazard and violating federal rattle standards."

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"Dementiaville"

From The Independent:

Switzerland's 'Dementiaville' designed to mirror the past
Plan to build 1950s-style village for Alzheimer's sufferers divides geriatric-care experts
TONY PATERSON
TUESDAY 24 JANUARY 2012

[snip]
"Its detractors may end up dubbing it "Dementiaville", but Switzerland is brushing aside a debate raging among geriatric-care experts with plans to build a mock-1950s village catering exclusively for elderly sufferers of Alzheimer's and other debilitating mental illnesses."
[snip]

Read the full article

The Game Brain: "Anti-Aging" Games

From The New Yorker:

RE-START
by John Seabrook
30 January 2012 issue

Read the full piece

More of the weird social justice that Obamacare has given us

See this article from Cato. By reclassifying the status of one hospital in Massachusetts, a number of hospitals in that state by some bizarre bureaucratic mechanism receive more Medicare payment from the Federal Government while that amount is made up for by cuts to the rest of hospitals in the country.This is a big blob of social justice right in your face.

Redistribution of funds based on arbitrary government bureaucratic decisions seems to be a recurrent feature of Obamacare,one poster child for which was the early on exceptions of certain companies from some of the provisions of the law. "The secretary shall determine" theme plays over and over.

The core of laws such a Obama care is that the devilish details are placed in the hands of executive branch entities who can then dish out favors as they see fit and the factions (Madison's quaint term for special interest groups) that can gain or loose from those decisions busy themselves with efforts to bring about some decree of regulatory capture or just simple payoffs.

The crap of "crony capitalism" get wrongfully blamed on capitalism while in reality the rent seeking ( the quaint term economists use for privilege seeking ) is a phenomenon that has become gargantuan because of the progressive mindset's endless quest to give more and more power to the government and to focus that power and control into ever increasing aspects of people's lives. No, I have not forgotten big government conservative's hypocritical initiatives to do about the same,albeit with a different rhetorical cover. More power to the government and thereby more efforts to harness that power for one's focused individual interest paid for by everyone else. But isn't Obamacare furthering social justice?

January 23, 2012

Anti-vaxxers challenge younger docs' clinical skills

It's not often I see a good article in the lay press on health and medicine. This one from the Chicago Tribune is an exception. It goes like this: Many childhood diseases, thanks to vaccines, disappeared from the scene. A generation of doctors went through training without seeing a single case. They “learned” about these diseases once in med school from lectures and textbooks but never

Imipenem outdoes doripenem in ventilator associated pneumonia

---according to a recent announcement. Before getting into the report this might be a good time to compare some attributes of the four “penem” antibiotics approved in the U.S. Imipenem (Primaxin)---from rxlist: Approved for:Lower respiratory tract infections. Staphylococcus aureus (penicillinase-producing strains), Acinetobacter species, Enterobacter species, Escherichia coli, Haemophilus

January 22, 2012

Alzheimer's: A Caregiver's Classic, Updated

This blog post from the New York Times discusses "The 36-hour Day":

The Caregivers’ Bookshelf: An Alzheimer’s Classic
The New Old Age Blog
The New York Times
by Paula Span
January 20, 2012, 2:27 PM

Read the full blog entry

Brain Awareness Week (BAW, #BrainWeek)

From the Dana Foundation Blog:

Gearing Up for Brain Awareness Week
20 January 2012

[snip]
"Brain Awareness Week (BAW) is less than two months away (March 12–18) and here at the Dana Foundation we are excited...Remember, the Dana Foundation and the Dana Alliance for Brain Initiatives (DABI) are here to help. If you register your organization with DABI and become a BAW partner at www.dana.org/brainweek/, you’ll get access to free BAW materials. Each year hundreds of BAW partners from Texas to Morocco register events with DABI and receive fun and valuable materials and resources for free."
[snip]

Read the full blog entry

Hashtag it at #BrainWeek

Neuropsychology Abstract of the Day: Preventing Cognitive Decline

Exergaming and older adult cognition a cluster randomized clinical trial
Am J Prev Med. 2012 Feb;42(2):109-19
Anderson-Hanley C, Arciero PJ, Brickman AM, Nimon JP, Okuma N, Westen SC, Merz ME, Pence BD, Woods JA, Kramer AF, Zimmerman EA

Abstract

BACKGROUND: Dementia cases may reach 100 million by 2050. Interventions are sought to curb or prevent cognitive decline. Exercise yields cognitive benefits, but few older adults exercise. Virtual reality-enhanced exercise or "exergames" may elicit greater participation.

PURPOSE: To test the following hypotheses: (1) stationary cycling with virtual reality tours ("cybercycle") will enhance executive function and clinical status more than traditional exercise; (2) exercise effort will explain improvement; and (3) brain-derived neurotrophic growth factor (BDNF) will increase.

DESIGN: Multi-site cluster randomized clinical trial (RCT) of the impact of 3 months of cybercycling versus traditional exercise, on cognitive function in older adults. Data were collected in 2008-2010; analyses were conducted in 2010-2011.

SETTING/PARTICIPANTS: 102 older adults from eight retirement communities enrolled; 79 were randomized and 63 completed.

INTERVENTIONS: A recumbent stationary ergometer was utilized; virtual reality tours and competitors were enabled on the cybercycle.

MAIN OUTCOME MEASURES: Executive function (Color Trails Difference, Stroop C, Digits Backward); clinical status (mild cognitive impairment; MCI); exercise effort/fitness; and plasma BDNF.

RESULTS: Intent-to-treat analyses, controlling for age, education, and cluster randomization, revealed a significant group X time interaction for composite executive function (p=0.002). Cybercycling yielded a medium effect over traditional exercise (d=0.50). Cybercyclists had a 23% relative risk reduction in clinical progression to MCI. Exercise effort and fitness were comparable, suggesting another underlying mechanism. A significant group X time interaction for BDNF (p=0.05) indicated enhanced neuroplasticity among cybercyclists.

CONCLUSIONS: Cybercycling older adults achieved better cognitive function than traditional exercisers, for the same effort, suggesting that simultaneous cognitive and physical exercise has greater potential for preventing cognitive decline.

TRIAL REGISTRATION: This study is registered at Clinicaltrials.govNCT01167400.

PMID: 22261206 [PubMed - in process]

FDA: progressive multifocal leukoencephalopathy (PML) and Tysabri (natalizumab)

From the FDA:

FDA permits marketing of first test for risk of rare brain infection in some people treated with Tysabri
For Immediate Release: January 20, 2012

[snip]
"Today, the U.S. Food and Drug Administration allowed marketing of the first test to help determine the risk for a rare brain infection called progressive multifocal leukoencephalopathy (PML) in people using the drug Tysabri (natalizumab) to treat multiple sclerosis (MS) or Crohn’s disease (CD).

"The Stratify JCV Antibody ELISA test, when used with other clinical data from the patient, can help health care providers determine the risk for developing PML in MS and CD patients."
[snip]
Read the full press release

CBO give results (largely negative) on several buzz word medicare demonstration projects

Buzz words abound in the wonky sector of health care, a domain in which many commentators comment more than they actually do health care.

Here is a CMO report on 10 demonstrations projects which sought to test the operational results
of several buzz word projects.

Dr. Robert Centor gives a brief summary of some of the finding on his blog.See here.

In the Disease Management programs,the costs seemed to exceed the benefits.In three out of four "Value based payment" program there was little or no savings.This is similar to comments I made almost 5 years ago regarding a radomized trial that show no value for a particular disease management program.

Dr Centor said:

Boys and girls, this stuff is much more complex than these demonstration projects can address. Physicians really do their best out there.

You bet it is more complex.

"The curious task of economics is to demonstrate to men how little they really know about what they imagine they can design." FA Hayek.The Fatal Conceit.

Russ Roberts writing in his blog, Cafe Hayek said in regard to some or other government program

"So many things the government does are attempts to circumvent the bad things caused by something else they already do."

It seems to be there are a lot of buzz word filled initiatives that are, at least in part, efforts to try and undo the mess made by CMS price controls on physicians fees and the primary care destroying RBRVS .

January 21, 2012

A bad report card for Medicare's pilot projects

---according to a CBO study as reported in this Medscape piece: Most Medicare demonstration projects aiming to reduce costs and improve the quality of care — prime goals of healthcare reform — miss their mark, according to a new study from the Congressional Budget Office (CBO) published online Wednesday. The projects consisted of numerous P4P schemes, disease management programs and bundled

January 20, 2012

Neuropsychology Abstract of the Day: Cognitive Rehabilitation

Errorless learning in cognitive rehabilitation: A critical review
Neuropsychological Rehabilatation. 2012 Jan 16;
Middleton EL, Schwartz MF

Abstract

Cognitive rehabilitation research is increasingly exploring errorless learning interventions, which prioritise the avoidance of errors during treatment. The errorless learning approach was originally developed for patients with severe anterograde amnesia, who were deemed to be at particular risk for error learning. Errorless learning has since been investigated in other memory-impaired populations (e.g., Alzheimer's disease) and acquired aphasia. In typical errorless training, target information is presented to the participant for study or immediate reproduction, a method that prevents participants from attempting to retrieve target information from long-term memory (i.e., retrieval practice). However, assuring error elimination by preventing difficult (and error-permitting) retrieval practice is a potential major drawback of the errorless approach. This review begins with discussion of research in the psychology of learning and memory that demonstrates the importance of difficult (and potentially errorful) retrieval practice for robust learning and prolonged performance gains. We then review treatment research comparing errorless and errorful methods in amnesia and aphasia, where only the latter provides (difficult) retrieval practice opportunities. In each clinical domain we find the advantage of the errorless approach is limited and may be offset by the therapeutic potential of retrieval practice. Gaps in current knowledge are identified that preclude strong conclusions regarding a preference for errorless treatments over methods that prioritise difficult retrieval practice. We offer recommendations for future research aimed at a strong test of errorless learning treatments, which involves direct comparison with methods where retrieval practice effects are maximised for long-term gains.

PMID: 22247957 [PubMed - as supplied by publisher]

January 19, 2012

Neuropsychology Abstract of the Day: Assessment

This looks like a great contribution. I am looking forward to reading it.

Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21
Neuropsychology. 2012 Jan 16;
Gur RC, Richard J, Calkins ME, Chiavacci R, Hansen JA, Bilker WB, Loughead J, Connolly JJ, Qiu H, Mentch FD, Abou-Sleiman PM, Hakonarson H, Gur RE

Abstract

Objective: Examine age group effects and sex differences by applying a comprehensive computerized battery of identical behavioral measures linked to brain systems in youths that were already genotyped. Such information is needed to incorporate behavioral data as neuropsychological "biomarkers" in large-scale genomic studies. Method: We developed and applied a brief computerized neurocognitive battery that provides measures of performance accuracy and response time for executive-control, episodic memory, complex cognition, social cognition, and sensorimotor speed domains. We tested a population-based sample of 3,500 genotyped youths ages 8-21 years. Results: Substantial improvement with age occurred for both accuracy and speed, but the rates varied by domain. The most pronounced improvement was noted in executive control functions, specifically attention, and in motor speed, with some effect sizes exceeding 1.8 standard deviation units. The least pronounced age group effect was in memory, where only face memory showed a large effect size on improved accuracy. Sex differences had much smaller effect sizes but were evident, with females outperforming males on attention, word and face memory, reasoning speed, and all social cognition tests and males outperforming females in spatial processing and sensorimotor and motor speed. These sex differences in most domains were seen already at the youngest age groups, and age group × sex interactions indicated divergence at the oldest groups with females becoming faster but less accurate than males. Conclusions: The results indicate that cognitive performance improves substantially in this age span, with large effect sizes that differ by domain. The more pronounced improvement for executive and reasoning domains than for memory suggests that memory capacities have reached their apex before age 8. Performance was sexually modulated and most sex differences were apparent by early adolescence. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

PMID: 22251308 [PubMed - as supplied by publisher]

Concussion in Sport

From the CBC:

Concussion prevention effort features mobile app
Four sports organizations partner with government on new education programs
CBC News
Posted: Jan 19, 2012 11:27 AM ET Last Updated: Jan 19, 2012 3:19 PM ET

[snip]
Four sports organizations will receive $1.5 million in federal funding for new education programs designed to reduce concussions and other brain injuries in children and youth who play team sports.

The Public Health Agency of Canada's "Active and Safe" program is supporting a joint project of ThinkFirst Canada, the Canadian Centre for Ethics in Sport, the Coaching Association of Canada, and Hockey Canada to help coachers, trainers, parents, and athletes recognize and prevent serious brain injuries.

In announcing the funding in Ottawa Thursday, Minister of State for Amateur Sport Bal Gosal noted that an estimated 90 per cent of severe brain injuries were preventable if parents, coaches and the kids themselves knew more about the risks.

"We can't eliminate all injuries," Gosal said, "but we want to help parents and coaches predict the predictable and prevent what is preventable."
[snip]
Read full article

January 18, 2012

Neuropsychology Abstract of the Day: Assessment

N-backer: An auditory n-back task with automatic scoring of spoken responses
Behav Res Methods. 2011 Sep;43(3):888-96
Monk AF, Jackson D, Nielsen D, Jefferies E, Olivier P

Abstract

The n-back task is commonly used to load working memory (WM) in dual-task and neuroimaging experiments. However, it typically involves visual presentation and buttonpress responses, making it unsuitable for combination with primary tasks that involve vision and action, such as sequential object use and other tasks of daily living. The N-backer software presented here will automatically present and score auditory-verbal n-back sequences utilising the standard speech synthesis and recognition facilities that come with Microsoft Windows. Data are presented from an experiment in which 12 student participants carried out three tasks from the Naturalistic Action Test (NAT) while their attention was divided between the primary task and a continuous auditory-verbal 2-back secondary task. The participants' 2-back performance was scored in two ways: by hand, from video recordings, and automatically, using the software, allowing us to evaluate the accuracy of N-backer. There was an extremely high correlation between these scores (.933). The videos were also used to obtain a comprehensive error score for the NAT. Significantly more errors were made in the more complex NAT tasks when participants were 2-backing, as compared with when they were not, showing that the auditory-verbal n-back task can be used to disrupt sequential object use. This dual-task method may simulate the attentional deficits of patients with brain injury, providing insights into the difficulties they face in tasks of daily living.

PMID: 21424186 [PubMed - indexed for MEDLINE]

January 17, 2012

Learning Disabilities

A press release from the NIH:

NIH announces funding for new learning disabilities research centers
Centers in Boulder, Houston, Tallahassee, and Seattle
17 January 2012

"Funding for four centers to conduct research on the causes and treatment of learning disabilities in children and adolescents has been provided by the National Institutes of Health."

Read the full press release

Call for "Neurology Tsar"

From the Guardian:

NHS warned of 'neurology timebomb'
Call for 'neurology tsar' as growing numbers are diagnosed with Parkinson's, motor neurone disease and multiple sclerosis
The Guardian
Tuesday 17 January 2012

Read full article

Is the American College of Physician's new Ethical Manual an ethical game changer

Dr. Michael Kirsch, author of the blog, MD Whistleblower, thinks so; see here for his view.

Here is a money quote from his commentary: He begins with a quotation from the ACP Ethics Manual;

Physicians have a responsibility to practice effective and efficient health care and to use health care resources responsibly.

This is an ethical game changer. According to the updated ethics manual, physicians should consider preserving health care resources for the population at large, which may conflict with our patient’s interest. Now, we are told that we are ethically obligated not only to advocate for our own patient, but also for hundreds of millions of other patients. If this becomes standard operating procedure, how will it impact the doctor-patient relationship? Will patients, who are increasingly skeptical of the medical profession, trust us? Will they suspect that we are restraining their care to serve the greater good?

The camel's nose (along with other anatomical parts) that sneaked under the medical ethical framework tent was the publication of a physician's" Charter" (aka New Professionalism) which in a gigantic non sequitur gratuitously asserted that social justice was now a major element in what they said what was medical professionalism, stopping just short of explicitly saying it was part of ethics.However, it was not clear what the separation between professionalism and ethics really was. Now the ACP makes that final move equating social justice with preserving health care resources for everyone and somehow balancing that against the individual patient's interest as an ethical responsibility. Has the concept of fiduciary duty to the patient really been shoved down the memory hole?

This is an ethical game changer but sometimes the ACP spokespeople seem to write and speak about both the charter and the ethics manual as if nothing has really changed. For example, I offer the following quote from recent comments from the president of the ACP, Dr. Virginia L. Hood in her message printed in the ACP Internist of January 2012.

She refers to the 2002 publication of a "physician charter to confront the health care challenges of a new millennium ". She continues " As well as restating (my bolding) the principles of 'primacy of patient welfare,patient autonomy, and social justice' ,it outlined a set of professional responsibilities..."

The charter did not restate social justice;it gratuitously inserted it and certainly never explained how striving for social justice enabled physicians to confront the new challenges. Now Dr. Hood writes about it as if social justice had always been a key element of medical ethics. It may be a useful rhetorical tool to just assume away a controversial issue but it should be clear that social justice based on a utilitarian calculus to allocate health care " resources" was when the charter was published and continues to be a source of considerable controversy in the medical community.

In a 1988 Annals of Internal Medicine Article,Hall and Berenson made- what appeared to many of us who were raised medically with the "old" medical professionalism of fiduciary duty to the patients- a startling proposal:

"We propose that devotion to the best interest of each individual be replaced with an ethic of the best interest of the group for which the physician is personally responsible."

Dr. Edmund Pelligrino writing in 1995 asked in the ethics of a profession could be changed at will.

Judging on the basis of the New Professionalism and the statements in the recent ACP Ethics Manual, it seems like it has.

DrRich of the blog "The Covert Rationing blog also believes it is a game changer.Further he offers his view as to what the real import of the new ethics is in this passage:

And here is the real import of the updated Ethics Manual. It aims to assuage the guilty conscience of physicians who follow handed-down guidelines to the letter, even against their better medical judgment, instead of tailoring the application of those guidelines to the benefit of their individual patients'

Exactly. It is an 180 degree switch from the antiquated ,fuddy duddy "fiduciary duty" silliness of a by gone era.

The ethical physician of today (again quoting DrRich) is "to follow the best evidence , in particular the best evidence on cost-effectiveness" and

" it is now the ethical obligation for doctors to follow expert produced guidelines" ( see here for DrRich's full commentary).

It is of some interest (or irony) that the introductory section of the 6th edition of the American College of Physicians Ethics Manual was written by an attorney, Lois Synder and there was no mention of a physician's fiduciary duty to his patient .

I do have trouble reconciling the words of the manual-particularly those quoted above-with these comments regarding the new manual from Dr. Hood as quoted in the 1/11/2012 Modern Medicine, on line:

“We have to consider cost as one of the factors when we make medical decisions, because that’s in the best interest of our patients,” Virginia Hood, MBBS, MPH, FACP, an internist and nephrologist and president of the ACP, tells eConsult. “It shouldn’t ever be an overriding part of a decision, but physicians need to take it into consideration.”

She continues:We have been advocating for efficient care since 1984, but it’s been given a slightly greater emphasis because the costs of care are so much higher,”,

So what is it- a slightly greater emphasis on cost or a real ethical game changer in which the fiduciary duty of the physician to the patient is not mentioned. Dr Hood's words quoted above seem reassuring but the black letter words as written in the ethics manual seem to pit the needs of the individual against the nebulous and ambiguously defined common good. In "box no.4 which addresses "Patients First and stewardship of resources" it says in part there is a responsibility to provide "parsimonious care that utilizes the most efficient means" [for diagnosis and treatment] . That sounds to me to be more than a slightly greater emphasis.

Also seemingly contrary to the representation that the new ethics manual really does not represent a major shift are several comments found in the editorial by Dr. Ezekiel Emanuel.(3 January 2012,Annals Internal Medicine,volume 156.number 1.pg 56)

Emanuel says :"Here is a professional society unafraid of advocating the principle of cost-effectiveness." Here aren't we talking about stuff like amount of dollars per life year saved?

He continues :These positions on efficiency, parsimony and cost effectiveness constitute an important shift,if not in ethics , then in emphasis." and

"It goes well beyond the usual banalities to take brave stand on current issues".

January 16, 2012

Price controls have worked so well in medical care, let's do some more

Doing some more is exactly what the Administration is doing here with its case by case decision regarding how medical insurers do their business. Of course, this level of central plannng on a mico level is part of the disaster unfolding as we see Obamacare play out. See here for the newspaper account of the Secretary of HHS ordering an insurance company to rescind its rate increase.

Arnold Kling,a MIT trained economist,is fond of saying that economists do not hold back the good stuff when they teach economics. Rather they reveal the important stuff in econ 101. In econ 101 the effects of price controls are clearly spelled out.Price controls in the form of price ceiling create several things:
1.Shortages
2.reduction in quality of goods or services provided
3.Search costs including wasteful lines
4.loss gains from trade
5.allocations of economic resources.

Here is what George Mason University economist, Don Boudreaux, has to say about the HHS actions in his typical trenchant style.

As millions of more people will have insurance cards,and think they now have access to medical care, consider how much worse the shortage of primary care ( think Medicare price controls) will be and how much longer and more wasteful and frustrating the lines in emergency rooms will be.

Addendum: See here for the blog entry by John Goodman entitled "How Doctors are Trapped" for a detailed discussion of some of the particular ways that the CMS physician fee price controls are destructive and demoralizing to physicians and patients .

Narcolepsy peak seen after 2009 pandemic flu

---with a phase delay of several months. It appears to be related to the pandemic itself, not the vaccination. The mechanism of narcolepsy is believed to be autoimmune destruction of certain hypothalamic neurons. Via Medscape Neurology Minute.

January 15, 2012

"Head Start: Use Your Head in 2012"

A special features section of the Guardian and the Observer:
Homepage

January 13, 2012

Fans of crony capitalism should love Obamacare

Writing in Forbes, Warren Meyers offered this eye catching title, " Crony Capitalism?Blame the Progressives."

Here is how it works as explained by Meyers in his posting in Forbes. See here for article.

Capitalism is simply the free exchange of individuals based on their self interest. There is no room for government subsides,bailouts or any of the other myriad forms of government interventions into the economy that favors one entity or groups over others. Whenever government has the power to dole out favors folks will seek those favors. They will seek out those privileges. The bigger the goverment, the more power to dole out favors, the more favor seeking and the more the targeted few benefit at the expense of the rest.

This privilege seeking activity in the jargon of the economist is called "rent seeking". Progressives as a group favor more goverment power to do all those things that they think wise leaders and technocrats can do much better than the people could do for themselves.Of course, Progressives share the blame with other big government politicians whether they be called big government conservatives or moderates or whatever.

Enter Obamacare as the poster child for what George Will has called the tendency of congress to pass intentions rather than statutes. What we get is legislation that outline an aspiration or a dream or a nice thought and then hands over the details which actually define the actions to various governmental appointees and agencies,who then become the target for possible regulatory capture or at the least effective lobbying efforts the results of which can be described as crony capitalism.

Here is an excellent essay on the nature of crony capitalism versus "Market capitalism" and how Obamacare is a poster child for the former.How does the furtherance of crony capitalism mesh with the alleged social justice that Obamacare was said to represent?

January 12, 2012

Neuropsychology Abstract of the Day: Route Navigation and Route Knowledge

Landmark sequencing and route knowledge: An fMRI study
Cortex. 2011 Dec 16;
Nemmi F, Piras F, Péran P, Incoccia C, Sabatini U, Guariglia C

Abstract

INTRODUCTION: The ability to navigate in a familiar environment mainly relies on route knowledge, that is, a mental representation of relevant locations along a way, sequenced according to a navigational goal. Despite the clear ecological validity of this issue, route navigation and route knowledge have been scarcely investigated and little is known about the neural and cognitive bases of this navigational strategy. Using functional magnetic resonance imaging (fMRI) we tested the validity of the predictions based on the main cognitive models of spatial knowledge acquisition about route-based navigation. METHODS: An order judgment task was used with two conditions (route and activity). Subjects were required to detect potential mismatches between a current sensory input and expectations deriving from route and activity knowledge. RESULTS: A medial occipto-temporal (e.g., lingual gyrus, calcarine cortex, fusiform gyrus, parahippocampal cortex) network was found activated during the route task, whereas a temporo-parietal (temporo-parietal junction) and frontal (e.g., Broca's area) network was related to the activity task. CONCLUSIONS: Functional data are congruent with cognitive models of route-based navigation. The route task activated areas related to both landmark identity and landmark order. Data are discussed in view of route-based navigation models.

PMID: 22225882 [PubMed - as supplied by publisher]

American Psychiatric Association "Slapps" down web site critical of DSM5

Dr. Bernard Carroll,former head of psychiatry at Duke,writing on the blog Health Care Renewal ,writes about an interesting conflict between the APA and a former editor of DSM. See here.

Dr. Allen Francis who edited DSM4 has been highly critical of the DSM process and particularly of the yet to be released DSM5.He expresses concern that psychiatry is being practiced less by psychiatrists and more by primary care physicians, who are busy and often s not very well trained in managing psychiatric problem and at times strongly influenced by marketing .

His criticism includes the charge that with the publication of DSM5, not yet released, there will be more patients diagnosed with DMS defined mental conditions as new diagnoses are being added and the criteria for others have been broadened. His comments regarding his view of the problems with DSM were appearing on at least one web site.


Now the APA,who owns DSM and profits from its publication and use, has sent out a cease and desist threat to the website previously known as "dsm5watch" Their argument was that the website to which he contributed a contained the letters DSM and that was a copyright infringement. The new name for the website is "dxrevisionwatch.wordpress.com"

The explanation for the strange spelling of "slap" in this post's headline is that the APA actions might be described by some as a "Strategic Lawsuit Against Public Participation". In this case only a threat.


See here for more comments by Dr. Francis and here for a reply by the APA to some of the criticism it has received lately.

More evidence demonstrating overuse of PPIs in hospitalized patients

In this study much of the inappropriate use was driven by “prophylaxis” and it was associated with an increased rate of C diff. The authors conclude: Proton pump inhibitors are frequently inappropriately prescribed to Medicine inpatients who do not have a valid indication and this practice is associated with an increase in C. difficile infection. Interventions are needed to curtail this

January 11, 2012

Brainwave 2012

Thank you Dana Foundation Blog for posting about this series at the Rubin Museum of Art, the homepage for which follows:

Brainwave 2012

From the homepage:

"Now in its fifth year, Brainwave brings people from diverse walks of life together to engage with neuroscientists in one-on-one conversations in order to better understand the workings of our minds. Starting February 2012 we will focus on how memory is processed in the brain."

The Rubin is located in Chelsea (NYC). Information about the schedule and the museum are available on the homepage.

The Guardian/Observer Memory Week

The Guardian/Observer Memory Week
Read the article

"The free 'Making the Most of your Memory' 24-page booklets, are available with the Guardian this Saturday 14 January and the Observer on Sunday 15 January."

Whither pharmacologic VTE prophylaxis in medical patients?

We've known for a while that it reduces VTE but there's never been a basis for a claim that it saves lives. According to this first ever high level study it doesn't. And these were sick patients, the type we consider high risk. Once again the “quality” movement jumped the gun. I guess even if there isn't a mortality benefit preventing the occasional VTE means something to the patient. For

January 10, 2012

Initial antibiotic selection for severe sepsis and septic shock: getting it right in the ER

This study in the Journal of Emergency Medicine retrospectively reviewed patients with severe sepsis and septic shock who had positive blood cultures, and compared the antimicrobial sensitivities of the isolates with the initial ER therapy: Effective antibiotic coverage was prescribed by emergency physicians in 82% (95% confidence interval [CI] .74–.88) of cases. Of the 25 patients who received

January 09, 2012

Metformin as an adjunct for type I diabetes???

From Medscape Ask the Experts. Among the possible benefits of metformin for DM 1 the article talks a lot about weight control. Which makes me wonder if all the subjects in the clinical studies cited really had DM 1 as opposed to DM 1.5 or DM 2 but requiring insulin for glycemic control.

January 08, 2012

Visual Technology

Technology is proving to be useful for education. There are examples of online education from grade school through universities. Visual technology can be especially useful for people to perceive how somethings are and how they function. Medical schools can make use of this for anatomy when bodies are in short supply or in altered states. One of the biggest challenges for health care is public education and this type of technology can be helpful. In that regard, health education can start at an early age and continue through life. It would be a healthier, longer, more productive and probably happier life.  

January 06, 2012

It's a Free Download: Today's News About Cognitive Decline

An open-access free download of the research paper upon which today's news in based:

Archana Singh-Manoux, Mika Kivimaki, M Maria Glymour, Alexis Elbaz, Claudine Berr, Klaus P Ebmeier, Jane E Ferrie, &
Aline Dugravot (2012). Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. British Medical Journal.

Article

Cognitive Decline

A report from the BBC:

Brain function can start declining 'as early as age 45'
BBC
5 January 2012
Last updated at 20:08 ET

[snip]

"The brain's ability to function can start to deteriorate as early as 45, suggests a study in the British Medical Journal.

"University College London researchers found a 3.6% decline in mental reasoning in women and men aged 45-49.

"They assessed the memory, vocabulary and comprehension skills of 7,000 men and women aged 45 to 70 over 10 years."

[snip]

Read the full article


Related report from the CBC:

Brain may start decline at age 45
Cognitive function may begin deteriorating earlier than previously believed
CBC News
Posted: Jan 5, 2012 6:45 PM ET Last Updated: Jan 6, 2012 7:14 AM ET

[snip]

"Memory, reasoning and comprehension skills can start to decline at age 45, research published Thursday suggests.

"The findings go against previous research that had found cognitive decline starts after age 60 — and highlight the importance of a healthy lifestyle in protecting the brain from dementia, researchers say."

[snip]

Read full article

More on the New Professionalism (medical) and what it is really about

The New Medical Professionalism has been a topic of concern to me for some time and I have tried to express my objections to what it represents on more than one occasion. See here.

But what I believe to be the definitive critique and explanation of what that document is all about has been published on the blog The Covert Rationing Blog by DrRich. See here.

Everyone should read it and share it with a colleague .Here is one quote:

To summarize, by the turn of the millennium doctors were being coerced to withhold healthcare from their patients at the bedside, and thus to violate their time-honored primary professional directive. The intent of the 2002 Charter on medical professionalism was to repair the problem (i.e., to cure the “frustration”), not by confronting the forces of evil doing the coercion, but rather, by simply changing medical ethics to make bedside rationing OK. And that’s just what the document did, though only after careful re-editing to make this radical change to medical ethics sound as benign as possible.

By explicitly endorsing the 2002 Charter on medical professionalism, the Sixth Edition of the ACP Ethics Manual thereby endorses healthcare rationing at the bedside – but it does so quietly, at arm’s length, so as not to stir up unwanted passions.

DrRich's topic for this essay is actually the New Ethics Manuel authored by the ACP and comments on the New Professionalism are offered in that context. Read his blog to learn about what Dr. Ezekiel Emanuel found particularly praise worthy regarding the new ethics.

Observations on the American College of Physicians Ethics Manual

So the sixth edition of the manual has just come out. You can go here to access a link to download the entire manual for free. For the most part the language is pretty standard, similar to other codes of ethics we're familiar with, such as that put out by the AMA. Here I will comment on some new areas of content and other aspects of the document that got my attention. The readability and

January 05, 2012

Neuropsychology Abstract of the Day: Aphasia and Communication

Rehabilitation targeted at everyday communication: can we change the talk of people with aphasia and their significant others within conversation?
Archives of Physical Medicine and Rehabilation. 2012 Jan;93(1 Suppl):S70-6
Wilkinson R, Wielaert S

Abstract

OBJECTIVE: To investigate whether aphasia therapy can change the talk of speakers with aphasia and/or their significant others within conversation.

DESIGN: Small number of intervention studies targeting conversations involving speakers with aphasia are reviewed. All are single case studies.

SETTING: Key assessment in the studies was an audio or video recording of 1 or more conversations between the dyad, usually made in the home setting. Intervention in these studies took place in the participants' home or another setting, such as a therapy room.

PARTICIPANTS: In all of the studies reviewed, the participants consisted of a person with aphasia (PWA) and a significant other, usually the PWA's spouse.

INTERVENTIONS: In all studies, therapy took the form of a behavioral intervention involving the provision of feedback to the significant other and/or PWA on their conversational behaviors uncovered by a conversation analysis assessment. Handouts, transcripts, discussion, and video feedback were used. Suggestions to permit participants to cope better with the effects of aphasia within conversation were given, and opportunities for practicing these strategies within conversation were provided.

MAIN OUTCOME MEASURES: Postintervention, 1 or more conversations involving the PWA and significant other were recorded in the same manner as the preintervention. Conversations were analyzed in relation to changes in the behaviors targeted in intervention, such as those involved in topic initiation or repair of linguistic errors.

RESULTS: Each of the studies reviewed presented evidence that the talk of people with aphasia and/or their significant others can be changed in conversation. In some studies the evidence is primarily qualitative, in the form of observed changes to conversational behaviors postintervention. Some studies produce stronger evidence by combining qualitative and quantitative analyses of change.

CONCLUSIONS: There is evidence that intervention targeting conversations involving an aphasic speaker can achieve change. Future studies should move beyond single case designs, include more robust, quantifiable evidence of change, and provide evidence of maintenance of change.

PMID: 22202194 [PubMed - in process]

CDC developing seed virus for A(H3N2)v

---as a step toward possible vaccine development, just in case.

Bryan Caplan tears apart Jonathan Gruber's graphic novel on health care reform

Jonathan Gruber is a major player in the health care wonk games and has recently written a graphic novel ( aka comic book) on health care" reform", an area in which he has written and worked extensively. See here for GMU economist Bryan Caplan's detailed shredding of that work.

I have blogged before on the paper by a MIT economist see here which "startled" the health care wonk world with the data driven observation that when folks have access to a government financed health care programs ( ie. Medicare) the demand for health care services increases about that which occurred when folks paid for those services with their own money.

On that issue Caplan says the following:

Gruber explains the basic facts about health care costs: they're rising, and government picks up much of the tab. But he almost totally neglects the connection between the two. Medicare and Medicaid vastly increase demand for health care. There's no denying it. Imagine how much more affordable health care would be if these programs had never been adopted - or if they were abolished.

Let's see if I get it.People tend to spend other people's money with less prudence that when spending their own. I think Milton Freeman might have made that point.

January 04, 2012

Catheter directed thrombolysis to prevent post thrombotic syndrome after DVT---an evolving story

This open-label randomized controlled trial reported a reduction in PTS attributable to local thrombolytic therapy in patients with iliofemoral DVT. The NNT was 7 and there was a downside of bleeding. The authors recommend the treatment, on top of conventional anticoagulant therapy, for patients with upper thigh DVT extending into the iliac, if appropriate expertise is available at the treating

January 03, 2012

A(H3N2)v: the next pandemic?

Last fall the CDC reported two cases of infection with this novel influenza strain in children in Indiana and Pennsylvania. By the end of 2011 that number had increased to 12, involving 5 states. So what's up with this? What is it? It's a hybrid of a swine H3N2 known for several years, containing a genetic segment from the 2009 novel H1N1 strain. Human to human transmission capability? If so

Some Lessons From Finland

In the 1960s Finland had the world's highest rate of deaths from coronary heart disease and the Province of North Karelia was the highest. The North Karelia Project was launched in 1971 to address this situation. Prevention was chosen as the most effective public health solution. "The general idea was to transform the social and physical environment of North Karelia. After an initial 5-year period, the project was extended locally, and its findings diffused nationwide to promote prevention throughout Finland. An integrated approach to prevention was central to success of the project. The risk factors for cardiovascular disease-unhealthy diet, smoking and physical inactivity-are risk factors for many chronic diseases. Rather than a number of vertical disease specific programs, an integrated approach targets the main common behavioral risk factors." Thinking advanced from a focus on risk factors for individuals into a broader emphasis upon the needs for society, environment and community to be supportive for health and to enable healthy living, i.e. a more comprehensive approach based on health determinants. Social marketing was an important aspect of the North Karelia Project. Dramatic changes were observed in risk-related lifestyles and risk factors in the people of North Karelia and this was associated with substantial reduction in population-wide rates of cardiovascular disease. With the nationwide roll-out of activities, the prevalence of risk factors and death due to cardiovascular disease began falling throughout Finland.

The North Karelia Project was adapted by cardiologists at Mayo Clinic for implementation in Olmsted County, Minnesota and in 2002 it served as a model for initiating Healthy Greenville 2010, which has evolved into LiveWell Greenville. Communities with similar public health projects are New York City, Savanah, Louisville, Oklahoma City and Chicago. A recent report indicated a five percent decline in obesity among school children in New York City.

Education is directly tied to health status and it is interesting that Finland has demonstrated success with reform of its educational system.