May 19, 2012

Diversity provides color to the tapestry of human experience

Diversity provides color to the tapestry of human experience

Diversity provides color to the tapestry of human experienceI was recently appointed the Assistant Director of the Yale Cancer Center with the portfolio of Diversity/Disparities. While I’m not sure I’m the most qualified for this, it has gotten me thinking a lot about diversity, disparities, and what it means to achieve health equity. Too often, I think, we are plagued by narrow thinking … the impression that our only objective is to ensure minority accrual to clinical trials. It seems to me, however, that diversity is so much more. It is truly at the core of what we do, particularly as oncologists.


Read the rest of Diversity provides color to the tapestry of human experience on KevinMD.com.


Category: Physician | Tags: | No comment


Healthcare social media #HCSM - top articles

Here are my suggestions for some of the top articles related to healthcare social media in the past 2 weeks:

Social media “likes” healthcare: From marketing to social business. Social media and health care: opportunities and obstacles - PWC 2012 report, free download http://goo.gl/GtSgE

8 Chrome Extensions that Make Blogging Easier http://goo.gl/fFKye

"News Squares" for Chrome is a new visual RSS reader http://goo.gl/ZgO7Z

CDC Social Media Guidelines and Best Practices http://goo.gl/Sw0n - Twitter guide updated in Feb 2012.

"20 Days to High-Quality, Engaged Twitter Following (in just 20 minutes a day)" http://goo.gl/8T0xL - Mixed bag of advice, some good tips

There is an allergy/immunology wiki: "AI notes" http://goo.gl/Qt1iE - Not sure who's behind it, looks useful.

Medicine, Social Media and Clinical Excellence. Let’s do it. http://goo.gl/WgRDw -- Here is one of my related blog posts: Doctors are natural communicators - social media is extension of what they do every day http://goo.gl/2FzQb

Study: There is a kernel of truth to the popular term "Facebook stalking". Introducing new terms (to me) such as: cyber obsessional pursuit (COP) and obsessive relational pursuit (ORI), which are categories of cyberstalking and stalking, resulting in three factors: Covert Provocation, Public Harassment, and Venting. http://goo.gl/sgVys

How to find RSS feeds for Twitter accounts, Facebook pages, YouTube, other SoMe sites http://goo.gl/Q6tNg

Fake tweet stops Nashville doctor's lecture, plans for cruise http://goo.gl/Lj0mO

How to Create Your Own Website using Blogger - Step-by-Step Guide for Physicians http://goo.gl/tCd37

Science blogging and self-promotion? http://goo.gl/yGUqS

How To Deal With Information Overload http://goo.gl/h4CmL and http://goo.gl/wDv5

The articles were selected from my Twitter and Google Reader streams. Please feel free to send suggestions for articles to allergycases@gmail.com and you will receive acknowledgement in the next edition of this publication.


Necessary is a word best defined when looking back in time

Necessary is a word best defined when looking back in time

How do you define a “good” doc?  I was reading the patient responses to an article here on KevinMD.com and was saddened by how many of the patients were angry with their docs.  Anger is an unhealthy emotion!  One of the respondents was particularly angry about the “unnecessary” tests her doc performed on her and her family.

I have written about the vagaries of the term “unnecessary” in the past.  What makes a doc brilliant?  What makes a doc lousy?  How can the same doc be perceived as “brilliant” by some patients and “lousy” by others?


Read the rest of Necessary is a word best defined when looking back in time on KevinMD.com.


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Social media and medicine - Stanford University Grand Rounds

Graham Walker is one of the first medical bloggers. He went on a hiatus during his emergency medicine (EM) residency, and has now found new inspiration to blog as an EM attending at Stanford University medical center. This is his talk on social media and medicine at Stanford University Grand Rounds: http://youtu.be/qtkggenLmlE



Dr. Walker: This is my talk on the dissemination of medical information over time, how the internet and social networking are changing medicine, and how to use digital tools to be a better clinician at the bedside.

Here is Graham's list of Digital Tools to Improve the Specialty:
http://gmergency.tumblr.com/post/22727728700/stanford-grand-rounds-may-9-2012

Comments from Twitter:

Alice Ackerman, MD, @CloseToHomeMD: [You need to watch the video-Gr8 talk]


Happy 10th blogiversary to me #10yrsblog

Ten years, even though I have been typing this blog for the entire time, it really seems incredible.  I did not imagine 10 years ago that I would still be ranting and people would be reading.  My counter tells me that I have had 2.8 million visitors.  This does not include those who follow on twitter – 1626 followers and 2576 tweets – or read the blog on facebook.

I do plan to continue for now as I still find blogging fun, intellectually stimulating, and a great hobby.

Thanks for reading all these years.  I hope to continue making this a worthwhile read.

Saturday Safety Roundup

The CDC issued a new report on drowning this week, highlighting the fact that drowning remains "the leading cause of injury death among children aged 1-4 years."

Not surprisingly, there are many stories of drowning in this week's Saturday Safety Roundup, including:

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May 18, 2012

Fit Features: 5 New Movies That Tackle Health (Not Comic Books)

This may shock you, but there are films coming out right now other than The Avengers and Battleship. A handful of this weekend’s new releases—Hysteria, Virginia, Mansome—might even be described as “health related,” though that covers a broad spectrum of health topics (including: male body image, pregnancy, schizophrenia and the mental health possibilities of vibrators). Here’s our quick guide to new health-related movies—we promise, nothing based on comic books or video games (just pregnancy manuals and bizarre history).

Related posts:

Post from: Blisstree

Working Moms Have Awesome Lives, Are Way Less Depressed Than Stay-At-Home Moms

murphy brown babyA few weeks ago, we all learned a valuable lesson from 30 Rock: Murphy Brown lied to us, and women really can’t “have it all” (read: kids and careers). But according to a Gallup poll released this morning, working moms actually seem to have it down–they report the more overall happiness than either employed, childfree women, or stay-at-home moms. The stay-at-home moms, meanwhile, reported the highest levels of depression and anger, and the lowest levels of satisfaction.

This isn’t the first time that research based on self-reporting has indicated that staying at home with young kids can be emotionally difficult and lead to a lack of overall life satisfaction. In 2010, New York Magazine released a featured entitled “Why Parents Hate Parenting,” which ignited the anger of many a mommy-blogger. And earlier this year, Blisstree writer Deborah wrote about a study that found that being a stay-at-home mom is depressing; the stay-at-home moms were not amused. Immediately, a lengthy battle ensued in the comments, as mothers who didn’t work outside the home adamantly defended their choice to stay at home, and refuted the study’s findings.

What’s interesting about this poll, however, is how happy working moms seem to be. Despite the message that is consistently repeated in films, television, and the media, women who continue to work as parents are not only less stressed, when asked how they felt “yesterday,” they report more feelings of enjoyment and fulfillment than either childfree women or stay-at-home moms. Here’s a graph from Gallup:

stay-at-home-moms depression

As you can see, working mothers not only report getting smiled or laughed at more, they also experience the most happiness, and report that the word “thriving” best describes how they feel. And who doesn’t want that? Additionally, in several studies, working moms have also shown to be physically healthier,  and better at managing stress.

Finances, too, seem to have a lot to do with it (don’t they always?). Stay-at-home moms on the tightest budgets report the highest levels of stress and depression, while working moms–even low-income ones–experienced more joy. However, in situations where the median household income was under $36,000 per year, employed women without children were found to be the happiest and most thriving.

It shouldn’t be as surprising as it is that a career, which has long been shown to give women greater feelings of self-efficacy, empowerment, and even enjoyment in their personal relationships, would be part of the mix for a truly fulfilling life–and yet, there are so many societal forces telling women that staying at home is the best way to raise healthy, smart, engaged children. Could it be that working moms are the victims or poor PR, and that they’ve actually got the secret to awesome lives? Or, are they just more likely to report positively about their life choices in the face of scrutiny?

Each mom (or child-free woman, for that matter) has to choose what’s right for her life and her choices–but it seems that, for the most part, working moms really do have the best of both worlds.

Image via Politico

Related posts:

Post from: Blisstree

May 17, 2012

Has blogging helped my patients? #10yrsblog

How has blogging helped your patients?

As I struggled to imagine an answer to this question, I had to consider doctoring then and now.  This answer is all opinion, as I could not do a randomized trial of blogging versus not blogging.

I guess blogging has helped, because I believe blogging has made me more thoughtful.  I probably read a bit more, because I am looking for blogging subjects.

But this is really a weak answer.  I can think of many reasons to justify blogging, but helping my patients is really not one.

Crib Tents and Play Yard Tents Recalled

Tots in Mind Tent Recalls - Photo courtesy of the CPSCAbout 330,000 crib and play yard tents made by Tots in Mind, Inc. are being recalled because of strangulation and entrapment hazards.

There have been at least 27 reports of tent failures. These reports include the death of a two-year-old boy who became entrapped between his tent and play yard and a two-year old boy who sustained a catastrophic brain injury when his crib tent inverted and a broken rod trapped him at the neck.

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Promotion of Healthy Swimming Behaviors

Safe swimming isn't just about prevent drownings.

You also want to make sure your kids stay healthy while they are swimming and that they don't get other people sick. But how do people learn about healthy swimming?

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New Drowning Report from the CDC

We get frequent reminders about how common drowning is, so it likely isn't a surprise that a new report from the CDC that was released today, "Drowning - United States, 2005-2009," states that "drowning is a leading cause of unintentional injury death worldwide, and the highest rates are among children."

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Poison Ivy

You can help kids avoid poison ivy by showing them where it is and what it looks like... - Photo by Vincent Iannelli, MDAs cold and flu season ends, another season begins.

For many, it means the start of spring allergy season. A lot of people also know it as poison ivy season.

Although poison ivy plants can trigger a rash year round, as the weather warms up and everyone spends more time outdoors, that means a lot more opportunities to get exposed to poison ivy and get a poison ivy rash.

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May 15, 2012

Are you working too hard?

If you ask most people, they will say they are working too hard.

But what if you ask their kids?

A new study by the Australian Institute for Family Studies found that about one in three 10-year-old children say their parents work too hard.

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May 12, 2012

The Latest Hand Sanitizer Dangers

We have all heard about the dangers of hand sanitizer over the years.

Dr. Gupta first warned us about the dangers of hand sanitizer back in 2007, when he highlighted the fact that hand sanitizer contains ethyl alcohol, the "same stuff in wine, beer and Jack Daniels." He went on to talk about all of the calls to poison control, likely from parents of kids who accidentally ingested hand sanitizer.

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Drinking Water Week

Drinking Water Week - Photo courtesy of the American Water Works AssociationThis is Drinking Water Week, a great time to remember that "the United States has one of the safest public drinking supplies in the world."

Remember, "tap water not only provides water for daily activities such as drinking, bathing, and cooking, it also benefits the entire community by providing water to serve businesses, schools, and hospitals, and to promote overall health."

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Cosmetic treatment of fever not warranted

We practice in an era of outcome based medicine. It’s not enough anymore, at least when it comes to things like blood pressure and blood sugar, just to treat the numbers (cosmetic treatment).  Why, then, in everyday practice, don’t we apply the same rigorous skepticism to the problem of fever? A recent study in Critical Care looked at the question. Lowering of body temperature was not

Saturday Safety Roundup

This week's Saturday Safety Roundup includes stories of:

  • a 5-year-old girl in Lancaster, Pennsylvania who is in critical condition after being shot in the head with a BB gun (Crosman Recruit) by her brother
  • a 2-year-old girl in Aiken, South Carolina who drowned in the family's backyard pool. She had been left in the front yard with her three siblings for just a moment, after which her father couldn't find her, until he discovered her in their above ground pool.
  • a 15-month-old girl in Las Cruces, New Mexico who was mauled to death by her family's pit bull
  • a 15-year-old in Franklin, Tennessee who died when the golf cart she was riding in with other kids down a steep hill blew a tire and crashed
  • a 2-year-old in Columbus, Ohio who died when the minibike he was riding on with two older children crashed into a pickup truck
  • a 15-year-old in Boulder City, Nevada who is in a medically induced coma after crashing because he hit a rock while riding his skateboard. He was not wearing a helmet.
  • a 4-year-old in Vermillion, Ohio who is in critical condition after being run over by her mother on a riding lawnmower
  • a 5-year-old in Forest Hill, Maryland who had both feet amputated after her father backed over her on his lawnmower
  • a 13-year-old in Livermore, California who died while riding his skateboard and colliding with the side of a pickup truck at the bottom of a hill
  • a 4-month-old in Erlanger, Kentucky who was hospitalized after being left in a hot car for at least 45 minutes. His mother and grandmother both thought he was with the other person.
  • a 3-year-old in West Jordan, Utah who had head trauma after falling out of a 2nd story window. He had pushed on a screen and fell out the window onto the concrete patio below.
  • a 2-year-old in Nebraska who died after falling off a horse
  • a 5-year-old in Clarksville, Tennessee who nearly drowned after falling into the grease pit near the picnic tables at a Sonic restaurant when she stepped on a dislodged man hole cover
  • a 4-year-old boy in Steuben County, New York who drowned in a pond after he likely fall off a newly built dock
  • a 2-year-old girl in Harrison County, Texas who drowned in an above ground pool in the family's backyard when her floatie slipped off and she got overlooked while a lot of kids were swimming in the pool
  • an 8-year-old in Pell City, Alabama who drowned in Logan Martin Lake while visiting with family and friends
  • an 18-month-old in Penbrook Pines, Florida who drowned in a lake near her home
  • a 4-year-old in Texas who drowned while playing with other children near the bank of a park in Lake Waco
  • a 6-year-old in Houston, Texas who drowned in an apartment complex pool
  • a 7-year-old in Tomah, Wisconsin who was hospitalized for four days and required 100 stitches after being attacked by a stray pit bull. He was taking his new bike, an early birthday present, for a test ride in his driveway.
  • a 3-month-old in Milwaukee who died after being electrocuted by a baseboard heater after falling out of her mother's bed
  • two children, including a 4-year-old, in San Antonio, Texas who died in a rollover accident. Neither was properly restrained in the SUV and they were both ejected during the accident.
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May 10, 2012

Neuropsychology Abstract of the Day: "Sluggish Cognitive Tempo"

Factor Structure of a Sluggish Cognitive Tempo Scale in Clinically-Referred Children.
Journal of Abnormal Child Psychology. 2012 May 8;
Authors: Jacobson LA, Murphy-Bowman SC, Pritchard AE, Tart-Zelvin A, Zabel TA, Mahone EM

Abstract

"Sluggish cognitive tempo" (SCT) is a construct hypothesized to describe a constellation of behaviors that includes daydreaming, lethargy, drowsiness, difficulty sustaining attention, and underactivity. Although the construct has been inconsistently defined, measures of SCT have shown associations with symptoms of attention-deficit/hyperactivity disorder (ADHD), particularly inattention. Thus, better characterization of SCT symptoms may help to better predict specific areas of functional difficulty in children with ADHD. The present study examined psychometric characteristics of a recently developed 14-item scale of SCT (Penny et al., Psychological Assessment 21:380-389, 2009), completed by teachers on children referred for outpatient neuropsychological assessment. Exploratory factor analysis identified three factors in the clinical sample: Sleepy/Sluggish, Slow/Daydreamy, and Low Initiation/Persistence. Additionally, SCT symptoms, especially those loading on the Sleepy/Sluggish and Slow/Daydreamy factors, correlated more strongly with inattentive than with hyperactive/impulsive symptoms, while Low Initiation/Persistence symptoms added significant unique variance (over and above symptoms of inattention) to the predictions of impairment in academic progress.

PMID: 22566025 [PubMed - as supplied by publisher]

May 09, 2012

Trampoline Recall

Trampoline Recall - Photo courtesy of the CPSCAbout 92,000 Sportspower BouncePro 14' Trampolines are being recalled because "the netting surrounding these trampolines can break, allowing children to fall through the netting and be injured."

The recalled trampolines were made in China and sold at Wal-Mart from February 2009 to 2012 for about $275.

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May 08, 2012

Awake mental replay of past experiences critical for learning

An NIH press release:

Awake mental replay of past experiences critical for learning
07 May 2012

Read the release

May 03, 2012

Dabigatran review

From the Journal of Medical Toxicology. Concerning bleeding complications: However, no therapeutic agent has been accepted to reliably reverse the hemorrhagic complications of dabigatran. As of yet, there is no solid evidence to guide management of bleeding complications; management should start with local control of bleeding when possible and transfusion of pRBCs if needed. Transfusion of

It's not just the QT interval, stupid!

Traditionally we look to the QT interval to assess the risk of Torsades des pointes ventricular tachycardia when monitoring the effects of certain drugs. Moreover, QT interval prolongation, rather than “twisting about the point” morphology, has been the defining characteristic of Tdp. But as pointed out in a recent post over at Clinical Correlations, that thinking is simplistic. Even

April 30, 2012

Physostigmine for anticholinergic delirium?

This piece from the folks at ToxTalk caught my eye. It's another example of medicine's swinging pendulum. It looks like physo has made a comeback for the treatment of anticholinergic poisoning. Why? Because these days the problem is so much less often the result of TCA overdose. Here's a little of the history. Back in the day TCA OD was the prototypical anticholinergic toxidrome. When I

April 27, 2012

Handwritten (white board) video tutorials on topics in medicine

I haven't examined the actual content but the topic list looks great. It's definitely worth a look. HT to Clinical Cases and Images.

April 23, 2012

Quick reference: anaphylaxis

From the Paucis Verbis series at Academic Life in Emergency Medicine.

April 21, 2012

Quick reference: interpreting intraosseous blood

From the Paucis Verbis series at Academic Life in Emergency Medicine.

Woo comes to the mall

Brought to you by Mayo Clinic.

April 20, 2012

PET scan for Alzheimer disease

The tracer has affinity for brain amyloid.  HT to Clinical Cases and Images.

April 19, 2012

I’m back

This blog is not dead. Priorities of life outside the blogosphere came calling. During the hiatus I realized how important a part of my professional life blogging has been. I have also reevaluated the focus, which will more clinical. An effort to improve the quality of clinical posts may result in a decreased frequency. Expect the new and improved Notes to resume apace in the near future.

April 18, 2012

Amyvid Approval

From Pharmalot blog, a good read about the Amyvid approval decision:

Should FDA Have Approved Lilly Alzheimer’s Agent?
Pharmalot
By Ed Silverman
April 9th, 2012 // 11:23 am

Read the full blog post

April 10, 2012

April 09, 2012

Can experts really answer all our health questions?

Drs.Pamela Hartzband and Jerome Groopman offer their views on the advice of health care experts, the too often discordant answers to health care questions and the role of "mind sets" or subjectivity on what is portrayed by some as scientific and objective answers.

See here for their comments in the WSJ Lifestyle section on line corresponding to versions of the column appeared in some of the print versions of the print WSJ on 3/31/2012. The title is "Rise of Medical Expertocracy"

The authors suggest that voices from both sides of what is usually ( and inadequately) labelled the political spectrum are claiming that they have the experts to answer all of our health care questions.They question the assumption that there is a right answer for all such questions and that "best practices" as formulated by a panel of experts will be based entirely on a scientific,objective impartial determination.

"For patients and experts alike, there is a subjective core to every medical decision. The truth is,despite many advances, much of medicine still exists in a gray zone where there is not one right answer"

Of course, expert panels use to varying degrees the available data sets, sophisticated statistical methods and epidemiological reasoning, but at the end of the process some one or some group has to make a value judgment.They have to say the risks are or are not worth the benefit.

The authors talk about "mind sets";the maximalists who tend to prefer doing everything or at least a lot and the "doubters" who worry that many (most?) treatments will be worse that the disease.They suggest that experts , as well, have mind sets that will influence the value judgment that they make after their objective analysis. So two experts can look at the same data and reaching opposite conclusions.Patients do this as well.

Since much of medical care is paid for by third parties,the advice of expert panels will likely have a major impact on their policies.

'Patients and doctors can differ with experts and not be ignorant or irrational.Policy makers need to abandon the idea that experts know what is best.In medical care, the "right" clinical decisions turn out to be those that are based on a patient's goals and values."

Amen, but that flies in the face of the over arching principal of the progressive medical mind set which is "Medicine is too important and too complicated to be left to the individual patient with advice from her patient".

My mind set or "priors" tends to warmly resonate with these views of Drs. Hartzband and Groopman and bristles when faced with the lamentations of some of the experts who accuse those whose advice differs from theirs as being ignorant of statistical concepts and seem themselves to be ignorant of the fact that their mind sets may influence their conclusions and advice.

Dr. Viriginia Moyer was the Chair of the U.S. Preventive Services Task Force at the time of the release of their recommendations regarding PSA screening for prostate cancedr. In her editorial in the Annals of Internal Medicine ( 6 March 2012,Vol 156,number 5, pg 392-393) she offers a dissection of the reasons why there is opposition to the Task Force's recommendation which advised against PSA screening.

While she mentions the possibility of some financial interests-both from companies and physicians whose daily work is to diagnose and treat certain screened-for conditions- playing a role in promotion of screening,her principal explanation is "physician Innumeracy". Simply put-those opposing the USPTF's PSA position just don't understand statistics. She also neglects to mention the possibility of financial interests ( third party payers) opposing screening. The Mafia rule of"follow the money" might just apply to both sides of that disagreement.

Dr. Moyer does not seem to recognize-or at least does not mention- the possibility that experts who know their way around NNTs (number needed to treat) and other statistical metrics and techniques as well or better than she might just look at the same data and reach a different value judgment. In fact they do and have even in regard to the issue of PSA screening.

Drs Hartzband and Groopman speak of a new form of paternalism "based on the assumption that Americans are not receiving "quality medical care".

" A lucrative industry has grown up to generate ever more medical metrics,to give report cards to doctors and hospitals, and to base payments on compliance with the "best practices".Yet beyond safety protocols, there is scant evidence that such measures improve our health"

April 05, 2012

Memory Program

I teach the first run tomorrow of my new 6-hr continuing-education program about Memory. Looking forward to it!

March 29, 2012

More on medical guidelines being hazardous to your health

A subset of pneumonia patients -those considered at risk of having a multi-drug bacterial etiology-did worse if their physician complied with ATS-IDSA guidelines according to a recent study. See here for reference to the article that was published on Lancet online.

I have blogged before about the dangerous tendency of guidelines tendency to cause unintended consequences and talked about the idiotic four hour pneumonia rule, one unintended consequence of which was the treatment of non-pneumonia patients for pneumonia within the four hour deadline.Well at least the treatment was started within 4 hours.

My longest screed about guidelines can be found here.

Guidelines can be considered part of the mind that says " medicine is too important and too complicated to be left to the individual physician and individual patient." This dangerous mind set was made explicit and championed by the former header of CMS, Dr. Don Berwick who said :


"Today, this isolated relationship [ed. the individual doctor-patient ] is no longer tenable or possible… Traditional medical ethics, based on the doctor-patient dyad must be reformulated to fit the new mold of the delivery of health care...Regulation must evolve. Regulating for improved medical care involves designing appropriate rules with authority...Health care is being rationalized through critical pathways and guidelines. The primary function of regulation in health care, especially as it affects the quality of medical care, is to constrain decentralized individualized decision making.” (My bolding).

Yeah,that pesky decentralized decision making just gets in the wise of wise centralized decision making which history tells us worked out really well in the 20th century.

The best quality or guidelines rules are supported to varying degrees by randomized clinical trials but even here one should proceed slowly because the well known efficacy-effectiveness gap tolerates simplistic approaches poorly. RCTs are often small and have multiple exclusion rules and fail to capture the perplexing diversity of relevant pathophysiological variables (known and unknown) that coexist in complex, hospitalized patients. It is in the sickest patients that rules formulated by committees based on what-ever data or personal bias that the most harm can be done and in whom individual variation overwhelm premature generalizations and an eager rush to mandate treatment rules.No, all guideline writers do not always intend that their wisdom should be mandatory ( but some do) and write disclaimers at the end of the articles to that effect, but guidelines have a way of morphing from suggestions to dicta and rules the ignoring of which may have financial or other consequences for the rouge doctor.


The mandatory and quasi mandatory nature of guidelines or quality indicators as wielded by the CMS mandarins and other institutional elites become even more dangerous with the spreading use of the "disruptive physician" doctrine. Not only must you go by the rules you can't complain about them without incurring the wrath of the hospital's disruptive physician committee.This doctrine is a brilliant control mechanism.If you challenge the disruptive physician concept you are by definition disruptive.

March 26, 2012

Cardiac stress test before endurance exercise might just make sense

The party line (I mean the consensus of reasoned expert opinion by panels of highly educated people) has been there should not be stress tests before a person begins training for or entering a marathon because of some combination of the following reasons: low incidence of cardiac events in endurance races and shorter fun runs,large numbers of false positives noted on treadmill stress testings,and the dominant theory that the major cause of cardiac events precipitated by exercise is acute plaque rupture rather than fixed coronary artery stenosis.

An extensive assessment of cardiac events during long distance runs might change the thinking in that regard.

JH Kim et al reached that conclusion following their analysis of cardiac arrests associated with marathon and half marathon races in the US from 2000 to 2010.See here for ref.

The authors' data including races involving 10.9 millions runners and 51 men had cardiac arrests. Hypertrophic cardiomyopathy and atherosclerotic coronary disease were the two most common causes.

The authors said:

"The absence of coronary plaque rupture in these persons was surprising because prior data and expert consensus documents have suggested that exercise induced acute coronary syndrome result from atherosclerotic plaque disruption and coronary thrombosis.

Their findings suggested that rather than plaque rupture that there was an imbalance between oxygen supply limited by stenotic coronary arteries and oxygen demand greatly increased by the exercise.

So exercise testing would be useful to the extent that the exercise related events were due to fixed obstruction. Of course both mechanisms could be present alone or in combination in various people. A resting ekg should be helpful in alerting to the possibility of hypertrophic cardiomyopathy. But, of course, there is that new directive by the progressive medical elite for parsimonious care to take under consideration.

March 22, 2012

More spending leading to better care seems true in Canada also

Recently I blogged about data indicating that sometimes more (money spent ) is better (better outcomes in health care) as well as in most everything else even though you sometimes hear just the opposite from devotees who misinterpret and over interpret the Dartmouth Atlas data.

Now we have this JAMA article from Canada that suggests that outcomes for heart failure,hip fracture and some other conditions are better when more money in spent.

March 19, 2012

Guess what - Obamacare will cost more than one trillion over ten years

The hype leading up to the passage of Obama care included claims that the bill would protect the country from bankruptcy,bend the health care cost curve and boost health care quality. Now the projection for 10 years of Obamacare is for 1.76 trillion and by the time we can get a even finer tuned projection it will likely be twice what it was claimed to be. See here for the projection of OBM.

I guess the social justice will cost a little more as we watch 34 million new health care card carrying folks scramble for the shrinking number of primary care doctors who will see Medicaid and Medicare patients.

The one trillion dollar number seemed to play an important role in the push and pull going on before the health care bill was passed.The cost of the plan had to be less than one trillion and getting the projected cost to be less than one trillion apparently played a significant role in the bill finally being passed.However, the cost estimates were rigged and only three years later are we getting more realistic projections showing how much flim- flam was involved.

March 16, 2012

Neuroscience in Seattle

The Greater Seattle Brain Science Cluster
xconomy.com
Luke Timmerman
16 March 2012

Read article

Sometimes spending more on health care brings better outcomes -duh

The widely quoted data from the Dartmouth Atlas has been almost as widely misunderstood to mean "more is less". How something so counter-intuitive and contrary to much everyday experience could get so much argumentative traction is a testament to a cognitive weakness that even Dr. Kahneman failed to document and explain in his book Thinking Fast and Slow. Maybe he does, it is simply gullibility or buying into data that confirm your priors.

Dr. Ashish K Jha sets the record straighter .See here.

Here is part of what he had to say.

“The Dartmouth Atlas shows that among communities, there are large variations in health care costs and large variations in quality, and some with high costs also have low quality. This convinces a lot of people that there can be a free lunch—that if we can get spending down in high-costs communities like McAllen, Texas, to levels seen in Minnesota, where spending is low and quality is high, we can save money and improve outcomes. But how you implement this in policy is hard, and often policy makers misunderstand what to do."


Dr, Jha's study is certainty not the first to counter some of the over-blown nonsense about the relationship to spending and outcomes in health issue. Here is an earlier on post dealing in part with some of the enlightening work of Dr. Richard Cooper in that regard. Also here is a thoughtful discussion of Cooper's work by one of my favorite economists, Arnold Kling.

The Atlas used coarse grained data, regional variations in cost and outcome, but was used to make much more fine grained conclusions by those who hyped the study .Individual hospital or (God forbid) individual patient data were not analyzed yet policy recommendations were applied to the more fine grained entities.

March 14, 2012

FDA: Generic Lexapro

A press release from the FDA:

FDA approves first generic Lexapro to treat depression and anxiety disorder
14 March 2012

Read the full press release

Colon cancer screening - not for 75 years olds?

The headline references one of the latest recommendations from the American College of Physicians (ACP).Seven members of the Clinical Guidelines Committee of the American College of Physicians have "determined" that consistent with the principle of cost conscious,high value care that "clinicians should not screen adults aged greater than equal to 75 years or those with substantial co-morbid conditions ..with a life expectancy of less than 10 years ."

The reference is "Screening for Colorectal cancer: A Guidance statement from the American College of Physicians. Annals of Internal Medicine 2012:156;378-386.

This is in contrast to the less rigid recommendation of the USPSTF which said:

USPSTF recommends against routine screening for colorectal cancer in adults 76 to 85 years of age. There may be considerations that support cancer screening in an individual patients.

Kudos to the USPSTF for allowing something that might at least pass for " patient centered care" to actually be centered on the patient and her concerns and her particular set of facts and to have those considered by her and her physician rather than having the option of colonoscopy categorically excluded by a general rule based on age. Further, the opposite of kudos to the ACP committee for their recommendation for not doing so.

ACP quotes a study in the Archives of Internal Medicine that "suggests that colonoscopy is overused in elderly patients including repeated screening at less than 10-years intervals and routine screening of patients older than 80 years."

The referenced article( see here for abstract) was an analysis of a large sample of Medicare patients who received colonoscopy exams for screening and around 45% received an second exam in less than 10 years. This is evidence than a number of patients received exams sooner than the 10 years recommendation for repeat exam so in that limited sense there was "overuse". The logical leap from that article to the recommendations of no screening past age 75 is unsupported by evidence or articulated reasoning expressed in the Annals article.

Why not age 73 or 76 or 80 or 65?

The age choice appears arbitrary and the absence of an articulated waiver based on individual circumstances is surprising and you have to wonder what evidence was used to reach their conclusion.You have to wonder because the article seemed bereft of any supporting evidence.

The print boiler plate disclaimer at the end of the article says:

"Clinical guidance statements are "guides" only and may not apply to all patients and all clinical situations.Thus,they are not intended to override clinicians' judgment."

But what will be remembered and quoted will be the 75 years cut point.

Page 385 of the Annals article has a table with the left hand column having a heading of "high-value,cost conscious care" across from the age related cutoff and their general screening recommendations.The implication is that the age recommendation is consistent with this "principle" of high-value,cost conscious care.

However,invoking the new magic words "High-value,cost-conscious care" (HVCCC) does not substitute for offering an analysis of the data regarding the outcomes of colonoscopy in older patients,e.g. complications, positive findings and ( here is something radical) how did the patients value the procedure.

I cannot help but worry that whatever righteous and rational reasoning and good intentions lead to the notion of HVCCC , it will become like the term "patient centered care" meaning whatever the authors of articles chose to have it mean. There are certain tactical advantages to have an elastic, ambiguous concept . I am preparing some comments on the notion of "value" as it is being applied to medical issues,particularly in regard to the difference between the use of the term by certain business consultant gurus and its questionable transfer to medical care and the standard
definition of value as explained in introductory economics texts.

March 12, 2012

Memory: BDNF and microRNAs

Making memories: How one protein does it
The JHU Gazette
12 March 2012

[snip]

"Studying tiny bits of genetic material that control protein formation in the brain, Johns Hopkins scientists say that they have new clues to how memories are made and how drugs might someday be used to stop disruptions in the process that lead to mental illness and brain-wasting diseases.

"In a report published in the March 2 issue of Cell, the researchers say that certain microRNAs—genetic elements that control which proteins get made in cells—are the key to controlling the actions of so-called brain-derived neurotrophic factor, or BDNF, long linked to brain cell survival, normal learning and memory boosting."
[snip]

Read the full article

March 11, 2012

Brain Awareness Week is Here!




Visit the Brain Awareness Week homepage at the Dana Foundation!

March 04, 2012

Department of HHS makes economic breakthrough: declares there IS a free lunch after all

Nobel prize winning economist,Milton Friedman, is quoted as saying that economics could be summed up with two principles. 1) There is no such thing as a free lunch and 2)demand curves slope downward or ( in non econo-speak) people buy more when the price is lower and less when prices are higher.

Dr Friedman did not live long enough to see that his first principle overturned.

When the dictum of the HHS Department ordering employers to provide medical insurance that included paying for birth control pills hit a snag when the Catholic Church hierarchy raised a loud and righteous ruckus as it impacted Catholic hospitals and schools, necessity once again became the mother of invention.

The Secretary of HHS , in a move alleged to be compromise, declared that: no, the employer would not have to pay but rather the insurance company would. (see here).When challenged with the argument that the insurance company would simply increase the premiums,the Secretary replied;no, the insurance company would not be allowed to do so. Further, that order would actually save the insurance company money because the savings from medical costs not incurred because of the decrease in the number of pregnancies pregnancies would be greater than the cost of the pills. So, not only are the birth control pill free but provide a saving to the insurance company.So it is even better than a free lunch. The insurance companies should be happy to be forced to save money.

But this previously unrecognized saving ( which for some strange reason insurers never recognized on their own) is only the beginning. If taking statins and blood pressure pills decrease the risk of heart attack, should not insurance companies be giving those medications to policy holders as well. After all, generic pills are cheap enough and treating a heart attack is a big ticket item. The opportunities along these lines seem endless.Once insurance companies grasp this principle their profits will soar and they will begin to "give away" a lot of stuff even without government coercion.

Some would argue that these dicta from the Department of HHS make any contract that existed between the insurer and the insured a farce since for hundreds of years a contract based on force or coercion rather than mutual agreement of the parties was considered not valid.(See here for the comments from the Institute for Justice arguing that is exactly what the individual mandate does.) Those naysayers just cannot see the big picture which is that a new economic principle has been discovered- namely there can be a free lunch if the government says so.

Now HHS needs to get to work on the abrogation of Friedman's second principle; the demand curve thing.Recently an MIT economist re-discovered that principle in regard to medical costs and Medicare.She found that there was an increase in the quantity of care demanded once older folks had the Medicare card which made their health care cheaper. See here for my earlier post explaining the data and analysis employed by the economist to "discover" that people like to spend other people's money.

Might not the huge increase in the number of folks who will be given an insurance card ( or forced to buy one) pose a real problem as there is no concomitant increase in the number of physicians to provide that care.One solution would be for HHS to determine that people do not demand more services and goods when they are cheaper which would solve the problem of a physician shortage.

Getting those silly economic misconceptions out the way should really make Obamacare work more smoothly and all of the social justice embedded in the 2000 pages of the statute can emerge.

March 03, 2012

Neuropsychological Abstract of the Day: Alzheimer Clinical Trial

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Study of the Oral γ-Secretase Inhibitor BMS-708163 (Avagacestat): Tolerability Profile, Pharmacokinetic Parameters, and Pharmacodynamic Markers
Clin Ther. 2012 Feb 28;
Tong G, Wang JS, Sverdlov O, Huang SP, Slemmon R, Croop R, Castaneda L, Gu H, Wong O, Li H, Berman RM, Smith C, Albright CF, Dockens RC

Abstract

BACKGROUND: γ-Secretase inhibitors (GSIs) are being investigated for their potential to modify the progression of Alzheimer disease based on their ability to regulate amyloid-β (Aβ) accumulation. BMS-708163 (avagacestat) is an oral GSI designed for selective inhibition of Aβ synthesis currently in development for the treatment of mild to moderate and predementia AD. In addition to the desired effect on Aβ synthesis, GSIs affect Notch processing, which is thought to mediate some toxic adverse effects reported with this drug class. Avagacestat produced up to 190-fold greater selectivity for Aβ synthesis than Notch processing in preclinical studies and may therefore produce less toxic adverse events than other less selective compounds. Presented here are the results of the first in-human study for this new GSI compound. OBJECTIVE: The goal of this study was to assess the tolerability profile, pharmacokinetic properties, and effects on pharmacodynamic markers (Aβ, trefoil factor family 3 protein, dual specificity phosphatase 6, and hairy and enhancer of split-1) of single, oral doses of avagacestat in healthy, young, male volunteers. METHODS: This was a multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study in 8 healthy young men (age, 18-45 years) per dosing panel. Each study participant was randomized to receive a single dose of placebo (n = 2) or avagacestat (n = 6 for each dose) as an oral solution in 1 of 9 sequential dose panels (0.3, 1.5, 5, 15, 50, 100, 200, 400, and 800 mg). For determination of avagacestat, blood samples were obtained before dosing and for up to 144 hours after dosing. For participants in the 800-mg avagacestat dose panel, additional samples were obtained at 216, 312, and 648 hours. For 40-amino acid isoform of Aβ (Aβ(1-40)) assessment, plasma samples were collected before avagacestat administration and up to 72 hours after dosing. RESULTS: Avagacestat concentrations peaked quickly after oral administration and then had a biphasic decrease in concentrations with a prolonged terminal phase. Exposures were proportional with doses up to 200 mg. Avagacestat was well tolerated at single oral doses up to 800 mg, with a biphasic effect on plasma Aβ(1-40). Adverse events were predominately mild to moderate in severity with no evidence of dose dependence up to 200 mg. CONCLUSIONS: Results from this single-ascending dose study suggest that avagacestat was tolerated at a single-dose range of 0.3 to 800 mg and suitable for further clinical development.

ClinicalTrials.gov identifier: NCT01454115.

PMID: 22381714 [PubMed - as supplied by publisher]

Computerized Cognitive Testing

I noticed the abstract for this new paper earlier in the day. It should be a good read.

Bauer RM, Iverson GL, Cernich AN, Binder LM, Ruff RM, Naugle RI (2012). Computerized neuropsychological assessment devices: Joint position paper of the American Academy of Clinical Neuropsychology and the National Academy of Neuropsychology.
Archives of Clinical Neuropsychology (2012 Mar 1).

February 29, 2012

Neurohacks Lands at the BBC

From the Neurohacks blog:

Neurohacks column at BBC Future
27 February 2012
Read the blog posting

February 28, 2012

Neuroaesthetics

From the BBC:

Understanding the brain on dance
27 February 2012 Last updated at 23:29 ET

[snip]
"How does the brain perceive and interpret beautiful movement?

"This is one of the key questions being asked by scientists at Bangor University who have enlisted the help of a professional dancer in their quest to better understand how our brains process movement and how we learn by observation.

"Dr Emily Cross' research focuses on the relatively new field of science called neuroaesthetics which looks at how the brain perceives artistic endeavours."
[snip]

Read the full article

Upcoming Event: Cambridge Neuroscience Seminar (Cambridge, 20 March 2012)

The 24th Cambridge Neuroscience Seminar:

Translational Neuroscience
For full information, click here.

Too Much Medical Care

Yes, it is possible to have too much medical care and modern health care offers plenty of examples. Too much medical care leads to less health care, less than optimum health status and increasing costs. Medical care serves a necessary function but it needs to be counter balanced by individuals and the community promoting healthy nutrition and lifestyles. 

New Nature Neuropod

The February edition of Neuropod presented by Kerri Smith is up and is a great listen today. Listen to or download the edition and enjoy features about the connectome, thoughts on just how many neurons are present in the average human brain, and "The Good, the Bad, and the Monkey."

Just where did that number of 100 billion come from?

One number is sure: it is the 50th episode of this popular podcast. Congrats!

Enjoy!

Homepage and link to podcast

February 26, 2012

Can Science Ever Explain Consciousness?

The Guardian's Science Weekly podcast for this week examines consciousness.
"On 7 March at the Royal Institution in London, Science Weekly presenter Alok Jha will host a debate entitled Consciousness: The Hard Problem?


"To discuss this slippery subject ahead of the debate Alok brought the three leading researchers and thinkers who will be participating into the Science Weekly studio: Professor Anil Seth, co-director of the Sackler Centre for Consciousness Science at Sussex University; Professor Chris Frith, professor emeritus at the Wellcome Trust Centre for Neuroimaging at University College London; and Dr Barry Smith, director of the Institute of Philosophy at the School of Advanced Study at Birkbeck, University of London."Read the full article and listen to the podcast

February 25, 2012

Obit: Dr. Ulric Neisser

Ulric Neisser Is Dead at 83; Reshaped Study of the Mind
By DOUGLAS MARTIN
The New York Times
Published: February 25, 2012

"Mr. Neisser helped lead a postwar revolution in the study of the human mind by advancing the understanding of mental processes like perception and memory."

Read the full obituary

February 23, 2012

Charlie Rose: The Brain Series (Series 2)

The Charlie Rose show is airing episodes from Series 2 of its "Brain Series."

Series 2 is a series of episodes that deal with brain disorders.

Home page

Neuropsychology Abstract of the Day: Assessment

Effects of Practice on the Wechsler Adult Intelligence Scale-IV Across 3- and 6-Month Intervals
Clinical Neuropsychologist. 2012 Feb 21;
Estevis E, Basso MR, Combs D

Abstract

A total of 54 participants (age M = 20.9; education M = 14.9; initial Full Scale IQ M = 111.6) were administered the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) at baseline and again either 3 or 6 months later. Scores on the Full Scale IQ, Verbal Comprehension, Working Memory, Perceptual Reasoning, Processing Speed, and General Ability Indices improved approximately 7, 5, 4, 5, 9, and 6 points, respectively, and increases were similar regardless of whether the re-examination occurred over 3- or 6-month intervals. Reliable change indices (RCI) were computed using the simple difference and bivariate regression methods, providing estimated base rates of change across time. The regression method provided more accurate estimates of reliable change than did the simple difference between baseline and follow-up scores. These findings suggest that prior exposure to the WAIS-IV results in significant score increments. These gains reflect practice effects instead of genuine intellectual changes, which may lead to errors in clinical judgment.

PMID: 22353021 [PubMed - as supplied by publisher]

February 20, 2012

neuGRID

From Business Wire:

neuGRID, the European Online Diagnosis Tool for Alzheimer’s, Goes Global with outGRID and the ITU
20 February 2012

"neuGRID, a cloud-computing infrastructure funded by the European Commission that stores and analyses a vast database of 3D brain scans, is now expanding globally to help find treatments for Alzheimer’s. This ground-breaking initiative will help develop a global online system to centralise and boost Alzheimer’s research initiatives."

Read full article